Single-event multilevel surgery SEMLS approach is regarded as the golden standard in developed countries to improve gait and functional mobility in children with cerebral palsy CP.Unifi guest portal url
However, this approach is not always feasible in developing countries. Therefore, orthopedic surgery based on an interval surgery approach ISA is still commonly used in developing countries, although little is known about the long term outcomes of an ISA. Therefore, the aim of this study was to describe the gait patterns of adults with CP, who have been treated with ISA, which started more than 15 years ago. Twenty kinematic and nondimensional temporal-distance parameters were captured, while the overall gait deviation index GDI was also calculated.
Data of the adults with CP were compared to normative data of typically developing TD adults. The CP gait patterns were characterized by excessive hip flexion and hip internal rotation as well as a stiff-knee gait. Gait patterns suggest that derotation osteotomies potentially could have improved the long term gait patterns.
Cerebral palsy CP is described as a nonprogressive permanent disorder of the immature brain, which typically results in a wide range of secondary musculoskeletal abnormalities in childhood. In order to assess the effectiveness of different surgical interventions, more and more studies are using three-dimensional gait analysis 3DGA as a tool to measure the impact of surgical interventions on walking patterns. Before the introduction of SEMLS, which is defined as two or more soft tissue or bony surgical procedures at two or more anatomical levels during one surgical intervention, 5 children were generally treated on multiple occasions.
Despite the fact that ISA has been around for many decades and still performed in developing countries, no followup studies are available of adults with CP, who underwent these orthopedic interventions in childhood. Information about the gait patterns of adults with CP who underwent ISA will be highly valuable in: determining how mobile these adults still are, creating comparative data to be used in future studies regarding the additional benefits of a SEMLS approach on gait, and providing clinicians and patients with a reference as to what type of gait pattern can be expected based on an ISA.
Therefore, the aim of the study was to describe the gait pattern based on the 3DGA kinematics, nondimensional temporal distance parameters, and gait deviation index [GDI] in adults with CP, who received the first orthopedic surgery based on ISA more than 15 years ago, and compare this with typically developing TD adults. This study was approved by the Human Research Ethics Committee at the University of Cape Town and conducted in accordance to the principles of the Declaration of Helsinki.
Each participant provided written informed consent upon gaining satisfactory knowledge regarding the risks and benefits of participation. The participants were recruited from the database of a special need school for disabled children in Cape Town, South Africa. The criteria for inclusion stated that participants had to have been born prematurely and diagnosed with CP and spasticity in both lower limbs could have mild involvement of an upper limb unilaterally.
In addition, participants had to be ambulant at the time of research, with or without the aid of an assistive device.
The participants also had to have received standard care, including conservative treatment e. Preoperative clinical records from the physiotherapists at the school had to be available, including information about the child's physical e. Finally, for followup purposes, the participant had to live within a km range of the city of Cape Town.
Persons were excluded if they had been diagnosed with dystonia, athetosis, ataxia, hypotonia, and other neuromuscular disorders. Persons were also not accepted in the study if they had undergone a neurosurgical intervention, such as selective dorsal rhizotomy SDRin the past.Boardgames PC Game Reviews. Mil History Online. Login or Sign Up. Logging in Remember me.LINK YOUR CP AND READ DB
Log in. Forgot password or user name? Kham Duc revisited. Posts Latest Activity. Page of 4. Filtered by:. Previous 1 2 3 4 template Next. Kham Duc revisited 15 Dec 11, My battalion, the 14th Combat Aviation Battalion was there providing Americal Division aviation support. The bigger picture, however, was not easy to compile. I scrounged every source I could find, catalogued over 60 pictures and created a dozen maps, all trying to make sense of it.
As I began sifting through all of this information, I decided that to deal with it chronologically was the only sensible way to cut away the fluff, myths and outright fairy tales and get to the real story.
What I have created has, I hope, very little of me in it. I have been sparing in my conjectures, conclusions or opinions in an attempt to get to the true courage and resourcefulness of a handful of Allied soldiers, Marines and aircrews. Such was the case with the evacuation of Kham Duc.So in love with you song
The event that would end as the often frantic and sometimes confused evacuation started years earlier in political circles in Hanoi. In spite of the U. American bombing had exacted a high price from the North Vietnamese people, and in spite of a brave face, the toll was beginning to show. A somewhat stable government under South Vietnamese President Nguyen Van Thieu had emerged, reducing Viet Cong control of the rural areas thereby greatly impacting National Liberation Front recruitment, food and tax sources.
Viet Cong guerilla main force and NVA units were losing an average of 15, men per month by the end of Viet Cong recruiting netted an average of only 3, per month and new NVA deployments south only numbered about 7, troops per month.
The math was easy. More NVA regular units would have to be committed. The North Vietnamese were very thorough in analyzing failure. After identifying the causes of a setback, they explored history to see if that situation had occurred before and what action had been taken then, and if it succeeded. They pulled out the files from and the Viet Minh struggle against the French.
At that time, they had sought action from the French Communist Party and other sympathetic organizations to cause disruption at home while Ho Chi Minh proclaimed loudly at a press conference that he was ready to negotiate peace. He did not mention at the press conference that he had just ordered Dien Bien Phu to be taken.
For the present conflict, a third direction would be attempted.Account Options Sign in. Top charts. New releases. Add to Wishlist.
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Community spread becoming main cause of COVID-19 infection in Canada: Tam
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Deputy chief public health officer Dr. Howard Njoo said when the virus first came to Canada, 80 to 90 per cent of cases were linked to travel abroad. But in the last week, nearly 90 per cent of cases reported to the public health agency came from spread of the virus within the community.
If Canada is going to get a handle on community spread, social distancing and maintaining a two-metre barrier between people is essential, she said. She noted the importance of understanding how the virus is spreading within communities, as this will have an impact on steps taken to stop transmission. For example in British Columbia, several clusters of cases and deaths have occurred within long-term care facilities, which has led to stringent protocols being enacted within these facilities to protect their more vulnerable residents.
She also pointed to a dental conference in B. With conferences and large gatherings now banned, this type of transmission risk is now lessened, Tam said. People identified with the illness now likely caught it from exposures up to three weeks ago, which is why health officials hope restrictive social distancing policies enacted across Canada in the last two weeks will start to show in upcoming data. Tam acknowledged the backlogs in testing for the virus have been frustrating, but says work is ongoing to find ways to hasten results.
NearlyCanadians have been tested, with an average of 10, people tested per day. Also on Tuesday, passengers from the Grand Princess cruise ship who completed their day quarantine at CFB Trenton and are symptom-free have been released.
Those who continue to have symptoms will remain until they're healthy. Search Search CP24 X. But the trend is now turning toward community spread. News Tips Report Errors. Top Videos false. Local News. World News. Governors feel heat to reopen from protesters, president Nations debate whether to relax pandemic restrictions as job loss bites.
Pancreatic ductal adenocarcinoma is a devastating disease, characterized by a rapid progression and poor treatment response. Using gene expression profiling of pancreatic cancer tissues, we previously identified periostin as a potential diagnostic and therapeutic target.
In this study, we report the overexpression of periostin in a larger set of pancreatic cancer tissues and show that although the periostin transcript is exclusively expressed in tumour cells, the protein product is only detected in the extracellular matrix adjacent to cancer cells.
Using an enzyme-linked immunosorbent assay ELISA assay, we show significantly increased levels of periostin in the sera of pancreatic cancer patients compared to non-cancer controls. We demonstrate that periostin promotes the invasiveness of tumour cells by increasing the motility of cells without inducing expression of proteases, and enhances the survival of tumour cells exposed to hypoxic conditions.Oscar proud yelling trudy
These findings suggest an important role of periostin in pancreatic cancer and provide a rationale to study periostin for diagnostic and therapeutic applications. Pancreatic ductal adenocarcinoma PDAC is the fourth leading cause of cancer-related deaths in the industrialized world Jemal et al.
This is due to both a paucity of diagnostic tools to detect early stages of the disease and a poor outcome following chemotherapy and radiation therapy even when combined with surgical excision of the tumour DiMagno et al. Therefore, a better understanding of the molecular mechanisms involved in pancreatic cancer progression is urgently needed to identify novel molecular targets for early screening and to develop new therapeutic approaches.
To look for new candidates, our laboratory has recently performed global gene expression profiling studies of PDAC compared with normal pancreatic tissue Crnogorac-Jurcevic et al. Periostin was identified as a potentially promising candidate for involvement in the pathogenesis of this disease and was chosen for further characterization.
Periostin has a typical signal sequence, followed by a cysteine-rich domain, four repeated and conserved domains and a C-terminal hydrophilic domain Takeshita et al. A similar structure was reported for fasciclin I, a cell adhesion molecule involved in the development of the central nervous system of insects Zinn et al. Periostin was found to be overexpressed in various types of human cancer such as lung Sasaki et al. Although these reports implicate periostin in tumour spread, the functional role of this protein is poorly described and recent publications report conflicting data.
While one report demonstrated that ectopic expression of periostin enhanced metastatic growth of colon cancer by preventing stress-induced apoptosis in cancer Bao et al. In this study, we investigated the expression and spatial localization of periostin in human pancreatic cancer tissues and tumour cell lines, as well as quantifying periostin levels in a large series of serum samples.
We used recombinant periostin to examine the biological role of this protein in two key elements of pancreatic cancer cell biology: malignant invasion and resistance to cell-death. Furthermore, we identified the cell surface receptor of periostin in pancreatic cancer cells and the associated cell-signalling pathway that is likely to contribute to the development of this aggressive cancer. High levels of periostin expression detected in pancreatic PDAC specimens. Periostin mRNA signal was detected in the cytoplasm of tumour cells arrows whereas the stromal cells arrowheads do not show any evidence of periostin mRNA expression.
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